Progress of research in the application of ultrasound technology for the treatment of Alzheimer's disease

扫码查看

原文链接

万方数据

外文摘要：Alzheimer's disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive deterioration.The presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer's disease.The use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent years.As a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive deficits.This article provides a summary of the application of ultrasound technology for treating Alzheimer's disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound therapy.Emphasis is placed on the benefits of introducing these treatment methods and their potential mechanisms.We found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-β plaque deposition.We believe that ultrasound is an effective therapy for Alzheimer's disease,and this review provides a theoretical basis for future ultrasound treatment methods.

外文关键词：

Alzheimer's diseaseblood-brain barrierdrugsmagnetic resonance imaging-guided focused ultrasoundmicrobubblesscanning ultrasoundultrasoundultrasound stimulation

作者：

Qiuquan Cai、Lianghui Meng、Meina Quan、Ling Wang、Jing Ren、Chenguang Zheng、Jiajia Yang、Dong Ming

展开 >

作者单位：

Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin,China

Innovation Center for Neurological Disorders,Xuanwu Hospital,Capital Medical University,Beijing,China

Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory,Tianjin University,Tianjin,China

Tianjin Key Laboratory of Brain Science and Neural Engineering,Tianjin University,Tianjin,China

展开 >

出版年：

2025

DOI：

10.4103/NRR.NRR-D-24-00539

中国神经再生研究(英文版)

中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902

ISSN：1673-5374

年,卷(期)：2025.20(10)