首页|Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Pain is often comorbid with emotional disorders such as anxiety and depression.Hyperexcitability of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid neurotransmission.This review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain disorders.Improving understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these conditions.However,the mechanisms that regulate gamma-aminobutyric acidergic systems remain elusive.It is also unclear as to whether the mechanisms are presynaptic or postsynaptic.Further exploration of the complexities of this system may reveal new pathways for research and drug development.

anterior cingulate cortexanxietychronic paincircuitcommunicationcomorbiditydepressiongamma-aminobutyric acidergic neuronsparvalbumin neuronssynaptic transmission

Lu Guan、Mengting Qiu、Na Li、Zhengxiang Zhou、Ru Ye、Liyan Zhong、Yashuang Xu、Junhui Ren、Yi Liang、Xiaomei Shao、Jianqiao Fang、Junfan Fang、Junying Du

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Department of Neurobiology and Acupuncture Research,Third School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China

Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases,Third School of Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou,Zhejiang Province,China

Fuchun Community Health Service Center of Fuyang District,Hangzhou,Zhejiang Province,China

2025

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子:0.902
ISSN:1673-5374
年,卷(期):2025.20(10)