首页|Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

Exploring the role of N-acetyltransferases in diseases:a focus on N-acetyltransferase 9 in neurodegeneration

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Acetyltransferases,required to transfer an acetyl group on protein are highly conserved proteins that play a crucial role in development and disease.Protein acetylation is a common post-translational modification pivotal to basic cellular processes.Close to 80%-90%of proteins are acetylated during translation,which is an irreversible process that affects protein structure,function,life,and localization.In this review,we have discussed the various N-acetyltransferases present in humans,their function,and how they might play a role in diseases.Furthermore,we have focused on N-acetyltransferase 9 and its role in microtubule stability.We have shed light on how N-acetyltransferase 9 and acetylation of proteins can potentially play a role in neurodegenerative diseases.We have specifically discussed the N-acetyltransferase 9-acetylation independent function and regulation of c-Jun N-terminal kinase signaling and microtubule stability during development and neurodegeneration.

acetyl-coenzyme AAlzheimer's diseaseanimal modelscell deathdrosophilaeyehuman diseasec-Jun N-terminal kinase signalingN-AcetyltransferasesN-acetyltransferase 9neurodegeneration

Prajakta Deshpande、Anuradha Venkatakrishnan Chimata、Amit Singh

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Department of Biology,University of Dayton,Dayton,OH,USA

Premedical Program,University of Dayton,Dayton,OH,USA

Center for Tissue Regeneration and Engineering at Dayton(TREND),University of Dayton,Dayton,OH,USA

Integrative Science and Engineering Center,University of Dayton,Dayton,OH,USA

Center for Genomic Advocacy(TCGA),Indiana State University,Terre Haute,IN,USA

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2025

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子:0.902
ISSN:1673-5374
年,卷(期):2025.20(10)