首页|Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after injury.However,whether it is possible to stimulate neurogenesis and reconstruct cortical layers Ⅱ to Ⅵ in non-neurogenic regions,such as the cortex,remains unknown.In this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic injury.Our findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated neurons.Importantly,these new neurons reconstructed the architecture of cortical layers Ⅱ to Ⅵ,integrated into the existing neural circuitry,and ultimately led to improved brain function.These findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

adult endogenous neurogenesisbasic fibroblast growth factor-hyaluronic acid collagen gelcortical remodelingfunctional recoverymigrationmotor cortex injuryneural circuitsneural stem cellsnewborn neuronsproliferation

Yan Li、Peng Hao、Hongmei Duan、Fei Hao、Wen Zhao、Yudan Gao、Zhaoyang Yang、Kwok-Fai So、Xiaoguang Li

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Department of Neurobiology,School of Basic Medical Sciences,Capital Medical University,Beijing,China

China Rehabilitation Science Institute,China Rehabilitation Research Center,Beijing Key Laboratory of Neural Injury and Rehabilitation,Beijing,China

Center of Neural Injury and Repair,Beijing Institute for Brain Disorders,Beijing,China

Beijing Key Laboratory for Biomaterials and Neural Regeneration,School of Engineering Medicine,Beihang University,Beijing,China

Guangdong-HongKong-Macau Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,Guangzhou,Guangdong Province,China

Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou,Guangdong Province,China

Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong,Hong Kong Special Administration Region,China

Center for Brain Science and Brain-Inspired Intelligence

Department of Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing,China

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2025

10.4103/NRR.NRR-D-23-01706

中国神经再生研究(英文版)
中国康复医学会

中国神经再生研究(英文版)

影响因子：0.902
ISSN：1673-5374
年,卷(期)：2025.20(10)