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云南省一起热带紫褐裸伞中毒事件调查及毒素鉴定

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目的 对一起热带紫褐裸伞中毒事件进行快速毒素筛查和对患者临床症状及治疗进行讨论,以期为此类事件的处置及临床救治提供参考.方法 利用超高效液相色谱-三重四级杆串联质谱对中毒事件剩余的毒蘑菇进行检测,根据流行病学调查方法,收集病例资料,并结合调查结果和患者的肝肾功能指标进行分析.结果 从中毒患者食用的热带紫褐裸伞中检测出裸盖菇素及毒蝇碱,患者症状与裸盖菇素和毒蝇碱中毒症状相似,表现为幻觉、恶心、呕吐、腹痛、腹泻等,肝肾功能指标正常.结论 此次中毒事件是由热带紫褐裸伞中的裸盖菇素及毒蝇碱引起.
Investigation and toxin identification of a poisoning incident caused by Gymnopilus dilepis in Yunnan Province
Objective To provide reference for the disposition and clinical treatment of poisoning incidents,rapid toxin screening and the clinical symptoms and treatment of a case of Gymnopilus dilepis poisoning were conducted and discussed.Methods Ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry was used to detect the remaining poisonous mushroom in the contaminated food.Based on an epidemiological investigation,case data were collected.The results of the epidemiological investigation and the liver and kidney indexes of the patients were analyzed.Results Psilocybin and muscarine were detected in the Gymnopilus dilepis consumed by the patients.The symptoms were similar to those of psilocybin and muscarine poisoning,which included hallucinations,nausea,vomiting,abdominal pain,and diarrhea.The liver and kidney functions were normal.Conclusion The poisoning event was caused by psilocybin and muscarine in Gymnopilus dilepis.

Gymnopilus dilepispsilocybinmuscarineultra-high performance liquid chromatography tandem mass spectrometrypoison mushroomYunnan

陈汝梅、黄小芹、阮燕明、孙明月、陈敏、林佶

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云南省公共卫生与食物安全重点实验室云南省疾病预防控制中心,云南昆明 650032

热带紫褐裸伞 裸盖菇素 毒蝇碱 超高效液相色谱串联质谱 毒蘑菇 云南

2024

中国食品卫生杂志
中国卫生信息与健康医疗大数据学会

中国食品卫生杂志

CSTPCD北大核心
影响因子:1.173
ISSN:1004-8456
年,卷(期):2024.36(1)
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