首页|应用适体传感器检测食品中大田软海绵酸

应用适体传感器检测食品中大田软海绵酸

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大田软海绵酸(OA)在海产品中分布广泛,对食品安全造成极大威胁.因OA具有高毒性、小尺寸和低分子量的特性,使得其抗体的获得面临诸多困难.核酸适体SELEX筛选技术可针对小分子获得高亲和性、单一适体序列,在贝类生物毒素的检测中具备极大优势.本文对基于OA适体构建的生物传感器,如比色传感器、荧光传感器、电化学传感器等在OA快速检测中的应用进行了综述,并总结归纳了该类传感器的性能和应用潜力,讨论了适体传感器未来的发展方向,以期更好地促进其开发和应用.
Application of biosensors in the detection of okadaic acid in food
Okadaic acid(OA)is widely distributed in seafoods and is a remarkable threat to food safety.Owing to its high toxicity,small size,and low molecular weight,obtaining antibodies against OA is a complex and difficult task.The aptamer SELEX technology can be used to achieve high affinity and single aptamer sequences for small molecules.Accordingly,this technology has several advantages for the detection of shellfish biotoxins.This review highlights the applications of biosensors based on OA aptamers,such as colorimetric sensors,fluorescent sensors,electrochemical sensors,and so on,in the rapid detection of OA.A summary of the performance and application potential of these sensors is provided,and the development direction of aptamer sensors is discussed to better promote their development and application.

Okadaic acidaptamerSELEX technologybiosensorshellfish toxin

陈盼、李迎、杨丽霞、谭建锡

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长沙县综合检测中心,湖南长沙 410010

长沙市食品药品检验所,湖南长沙 410036

长沙海关技术中心,湖南长沙 410004

大田软海绵酸 核酸适体 SELEX技术 生物传感器 贝类毒素

长沙市自然科学基金项目国家市场监督管理总局科技计划项目

kq20141812020MK074

2024

中国食品卫生杂志
中国卫生信息与健康医疗大数据学会

中国食品卫生杂志

CSTPCD北大核心
影响因子:1.173
ISSN:1004-8456
年,卷(期):2024.36(3)