首页|克罗诺杆菌基因组学研究进展

克罗诺杆菌基因组学研究进展

扫码查看
克罗诺杆菌(Cronobacter spp.)是一类环境适应能力强、分布广泛的食源性条件致病菌,可通过污染婴幼儿配方奶粉等食品导致新生儿感染,并引发坏死性结肠炎、败血症以及脑膜炎等疾病,严重威胁着新生儿和早产儿生命健康.近年来,高通量测序技术和细菌基因组学领域的迅猛发展,极大促进了克罗诺杆菌基因组学分析、分子进化和变异机制、毒力基因、鉴定基因和耐药基因挖掘等方面的研究,这对防治克罗诺杆菌感染具有重要的科学意义.本文旨在对克罗诺杆菌基因组学的最新研究现状和发展趋势予以综述,为应用于预防和治疗克罗诺杆菌感染性疾病以及鉴定克罗诺杆菌新方法的建立提供重要的理论依据.
Research progress in genomic analysis of Cronobacter spp.
Cronobacter spp.are foodborne opportunistic pathogens known for their significant environmental adaptability and wide-ranging distribution.These organisms have the potential to cause neonatal infections through the contamination of infant powdered formula,resulting in serious diseases,such as necrotizing enterocolitis,sepsis or meningitis,thereby posing a serious threat to the health and life of newborns and premature infants.The recent rapid progress in high-throughput sequencing technology and bacterial genomics has greatly promoted research in areas such as the genomic analysis of Cronobacter,molecular evolution and mechanisms of variation,virulence genes,identification genes,and drug resistance gene mining.These advancements have significant scientific implications for the prevention and treatment of Cronobacter infections.This review aims to offer a thorough analysis of the present status and forthcoming directions in Cronobacter genomics research,providing essential theoretical groundwork for the development of novel approaches in identification,prevention,and treatment of Cronobacter infections.

Cronobacter spp.foodborne opportunistic pathogensgenomicswhole genome sequencing

熊棚、张慧娜、陆志、王磊、汪露

展开 >

三峡大学基础医学院,肿瘤微环境与免疫治疗湖北省重点实验室,湖北宜昌 443002

三峡大学基础医学院,宜昌市炎症与损伤研究重点实验室,湖北宜昌 443002

克罗诺杆菌 食源性条件致病菌 基因组学 全基因组测序

2024

中国食品卫生杂志
中国卫生信息与健康医疗大数据学会

中国食品卫生杂志

CSTPCD北大核心
影响因子:1.173
ISSN:1004-8456
年,卷(期):2024.36(9)