Objective To compare the clinical efficacy of delicate pulsed light(DPL)and optimal pulse technol-ogy-intense pulsed light(OPT-IPL)in the treatment of rosacea.Methods 40 patients with rosacea,admitted to The Seventh People's Hospital of Zhengzhou between February 2021 and February 2022 were enrolled as research subjects,and divided into DPL group(n=20)and OPT-IPL group(n=20)based on the different treatments they received.Patients in the DPL group were treated with DPL,whereas patients in the OPT-IPL group were treated with OPT-IPL.The water content of skin,trans-epidermal water loss,erythema,clinical efficacy,and occurrence of adverse reactions were compared between the two groups.Results After 4 weeks of treatment,there were no significant differences in the water content of skin or trans-epidermal water loss between the DPL group and the OPT-IPL group(t=0.283 and 0.581,P=0.779 and 0.565),and the clinical erythema assessment(CEA)score was significantly lower in the DPL group compared with the OPT-IPL group(t=2.566,P=0.014).After 4 weeks of treatment,the clinical efficacy was evaluated as markedly effective in 11 cases,effective in 8 cases and ineffective in 1 case in the DPL group,which showed no statistically significant difference compared with the OPT-IPL group(Z=-1.337,P=0.181)-6 cases markedly effective,11 cases effective and 3 cases ineffective.During the course of treatment,the incidence of adverse reactions in the DPL group was 15.00%,which was significantly lower than the corresponding 45.00%in the OPT-IPL group(χ2=4.286,P=0.038).Conclusion Both DPL and OPT-IPL can effectively improve the water content of skin,reduce trans-epidermal water loss,and repair the skin barrier function of patients with rosacea.However,DPL does better in improving erythema and fewer adverse reactions,presenting much higher value of clinical application.
维普
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