Objective To summarize and analyze the clinical efficacy of MEBO combined with perforator flap transfer in the treatment of third-degree burns on extremities.Methods 15 patients with third-degree burns on extremities,admitted to Nanyang Nanshi Hospital from January 2021 to January 2023,were treated with MEBO dressing change,and the perforator flap transfer was performed when granulation tissues grew well.The wound healing condition and joint function recovery were observed.Results The wounds of all the 15 patients were healed completely,and the healing time ranged from 35 to 75 days,with an average of 45.15 days.Mild hypertrophic scars were observed on healed skin but no obvious joint mobility disorder was found.Primary healing occurred in 12 cases,and secondary healing occurred in 3 cases(all the patients showed minor distal flap necrosis,which then turned better after debridement and MEBO dressing change).Conclusion The combination of MEBO and perforator flap transfer in the treatment of third-degree burns on extremities is conducive to wound healing and joint functional recovery,and the clinical efficacy is definite,deserving to be promoted in clinical practice.