Objective To systematically evaluate the clinical efficacy and safety of enteral nutrition in the treat-ment of severe burns.Methods Computer-based literature search was conducted to retrieve randomized controlled trial studies on early enteral nutrition treatment for severe burns published by November 2022 from the establishment of the following databases as PubMed,Web of Science,Cochrane Library,China National Knowledge Infrastructure(CNKI),Chinese Biomedical Literature Database,China Science Periodical Database(Wanfang),China Science and Technology Journal Database(VIP).The modified Jadad scale and funnel plots were used to evaluate the quality of the retrieved papers,and RevMan 5.4 software was applied to merge and analyze these documents.Results A total of 11 papers screened out from the retrieved literature were included in the study,with 753 severe burns patients involved.Meta-analysis showed that the wound healing time and time to positive nitrogen balance were significantly shorter in the enteral nutrition group compared to the parenteral nutrition group(SMD=-1.09 and-1.44,95%CI:-1.26--0.92,-1.67--1.21,both P＜0.00001).Serum albumin levels respectively on day 7 and 14 were significantly higher in the enteral nutrition group(MD=2.84 and 2.55,95%CI:1.77-3.92,1.43-3.67,both P＜0.00001),and the incidence of complications was lower in the enteral nutrition group(RR=0.43,95%CI:0.34-0.55,P＜0.00001).Conclusion Compared with paren-teral nutrition,early enteral nutrition treatment for patients with severe burns can significantly promote their wound healing,shorten the recovery time to positive nitrogen balance,improve serum albumin levels,and reduce the incidence of complica-tions,deserving to be promoted in clinical practice.
关键词
重度烧伤/肠内营养/肠外营养/白蛋白/Meta分析
Key words
Severe burns/Enteral nutrition/Parenteral nutrition/Albumin/Meta-analysis
维普
万方数据