Objective To study the clinical efficacy of omeprazole sodium for injection at different doses in the treatment of acute peptic ulcer bleeding.Methods 72 patients with acute peptic ulcer bleeding,admitted to The First Affiliated Hospital of Henan University of Science and Technology from May 2021 to May 2022,were enrolled as research subjects and divided into the high-dose group(n=36)and the routine dose group(n=36)based on the treatment dose.Patients in the high-dose group received an 80 mg intravenous drip of omeprazole sodium after routine endoscopic hemostasis,whereas patients in the routine dose group received a 40 mg intravenous drip of omeprazole sodium after routine endoscopic hemostasis.Hemostasis time,length of stay,clinical efficacy,change of intragastric pH value,and rebleeding rate were compared between the two groups.Results The hemostasis time and length of stay of patients were significantly shorter in the high-dose group compared with the routine dose group(t=2.213 and 3.158,P=0.030 and 0.002).After 3 days of treatment,the total effective rate of patients was 83.33%in the high-dose group,which was significantly higher than the corresponding 61.11%in the routine dose group(χ2=4.431,P=0.035).There was no significant difference in the 24-hour intragastric pH value between the two groups(t=0.786,P=0.434),but the time required to reach a pH value of 4.0 and 6.0 was significantly shorter in the high-dose group(t=2.072 and 2.321,P=0.042 and 0.023).One-month follow-up after treatment showed that the rebleeding rate in the high-dose group was 11.11%,which was significantly lower than the corresponding 30.56%in the routine dose group(χ2=4.126,P=0.042).Conclusion Compared with routine dose,high-dose omeprazole sodium for injection can effectively control bleeding symptoms of patients with acute peptic ulcer bleeding,shorten hemostasis and hospitalization time,increase intragastric pH value rapidly,and reduce the rebleeding rate,and the clinical efficacy is more definite.
关键词
不同剂量/奥美拉唑钠/急性消化性溃疡出血/止血/再出血
Key words
Different doses/Omeprazole sodium/Acute peptic ulcer bleeding/Hemostasis/Rebleeding
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