The limited ability of the body to fully repair large bone defects beyond critical sizes often necessitates the implantation of replacement material to promote healing.While the current clinical strategies to address such bone defects generally carry associated limitations,bone-tissue engineering approaches seek to minimize any adverse effects and facilitate complete regeneration of the lost tissue.Extracellular matrix,due to its excellent biocompatibility,unique biomechanical properties and biological activities,has been widely investigated as a scaffold in regenerative medicine.This review focused on hybrid constructs and modification on ECM materials,as well as its biological effects in vitro and in vivo.Application prospects in bone regeneration were also discussed.
bone transplantation materialsextracellular matrix materialscollagenbiocompatibilitybone tissue engineering
NETL
NSTL
万方数据
维普
