Research Progress of Nanomaterial Targeted Drug Delivery in Osteoarthritis Treatment
Osteoarthritis is a chronic,highly prevalent degenerative disease.Delivering drugs to the joints presents challenges,as free drugs injected into the joints are prone to degradation and rapid clearance through the lymphatic and blood systems.Nano-targeted drug delivery systems,designed with specific assembly and appearance modifications,offer significant advantages.They can increase the drug concentration at the arthritic site,improve efficacy,reduce toxicity,therefore,have been extensively studied for uses in osteoarthritis treatment.This review introduced current nano-drug delivery strategies that featured active targeting in treating osteoarthritis,summarized research work on nano-drug delivery systems enhanced by biotargeting ligands and biomimetic biofilms,highlighting their advantages and limitations.In addition,we discussed the potential future developments of nano-drug delivery systems,aiming to provide references and constructive suggestions for improving the past active targeting and modification strategies of nanomaterials.
osteoarthritisnanomaterialactive targetingdrug delivery system
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