Correlation between pathological biopsy of gastric antrum and Helicobacter pylori(Hp)infection in 13C breath test of children with peptic ulcer:An analysis of 111 cases
Objective To explore the correlation between the severity of gastric antrum inflammation by pathological biopsy and positive Helicobacter pylori(Hp)in children with peptic ulcer under electronic gastroscopy,and provide certain evidence-based basis for clinical diagnosis and treatment.Methods A total of 111 children who had peptic ulcers confirmed by gastroscopy at the Pediatric Department of the First Affiliated Hospital of Xiamen University from October 2019 to July 2021 were included as the observation subjects.General data were collected and various related indicators were analyzed at the same time,including as 13C breath test,pathological biopsy of gastric antrum,immunohistochemistry,etc.,in order to study the correlation between the severity of gastric antrum inflammation and positive Hp in children with peptic ulcer.Results Among 111 children with peptic ulcer,there was 1 gastric ulcer,108 duodenal ulcer,and 2 compound ulcers;among them 96 cases received 13C breath test,94 cases received gastric antrum biopsy and immunohistochemistry.All the 13 cases with Hp-positive in gastroscopy pathological biopsy had moderate to severe antral inflammation,and the difference between positive group and negative group was statistically significant(rank sum=931.5,P＜0.05).The same results were also found in 19 patients with positive 13C breath test(H=10.280,P＜0.05).The antral inflammation in patients with negative Hp in 13C breath test and gastroscopy biopsy was more mild,and the difference between positive and negative groups was statistically significant(rank sum=888.5,P＜0.001).Conclusion Hp infection is the main cause of maderate to severe inflammation in the gastric antrum of peptic ulcer;a positive Hp biopsy is more likely to reflect the severity of gastric antrum inflammation than a positive 13C breath test.Electronic gastroscopy is extremely necessary for children with a positive 13C breath test,which can give a stronger evidence-based proof for performing anti-Hp treatment.
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