Analysis of risk factors and prognostic outcomes of twin premature infants with pulmonary hypertension
Objective To analyze and summarize the risk factors and prognostic outcomes of pulmonary hypertension(PH)in premature infants.Methods The twins admitted to Women and Children's Hospital,Qingdao University,from January 2016 to June 2022 were taken as the research subjects.One of the twins was diagnosed with PH,and comparison of paired twins.The clinical data,risk factors and follow-up results were analyzed retrospectively.Results In this study,33 pairs of premature twins with PH were included.Compared to the control,a higher frequency of PH was observed in Twin's second and were small in terms of the age of gestation,the duration of respiratory support and the length of hospital stays(P＜0.05).There was no significant statistical difference in the prevalence of complications between the children of the two groups,such as persistent pulmonary hypertension,sepsis,neonatal asphyxia,intraventricular hemorrhage,neonatal respiratory distress syndrome,and congenital heart disease(P＞0.05).The incidence of moderate to severe BPD was higher in the PH group(P＜0.05).There were no significant differences in laboratory indicators between the two groups concerning the initial blood gas analysis,blood routine tests and bio-markers(P＞0.05).In the PH group,16 children were given early postoperative drugs to decrease pulmonary hypertension,as well as cardiotonic and diuretic medicines.The median follow-up time was 5.25 years,and there were no deaths during this period.At the age of 6 months,PH of 39.4％(13/33)returned to normal,and at 1 year old,81.8％(27/33)returned to normal.Conclusion This study takes premature twins as research subjects and compares the clinical date of PH in premature twins.The critical condition of early post-natal development,the use of a ventilator and the prolonged hospitalisation are factors that contribute to the development of premature infant PH,which is related to a moderate-to-severe BPD.81.8％of premature infants with PH return to normal within one year after birth.
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