Progress in the treatment of systemic autoinflammatory diseases
Systemic autoinflammatory diseases(SAIDs)are a group of genetic disorders characterized by recurrent or persistent inflammatory responses and multi-system involve-ment,where the innate immune system plays a major role in disease pathogenesis.Although pathway-directed targeted therapies such as JAK inhibitors,IL-1 pathway inhibitors,and TNF inhibitors have achieved good response in some SAIDs.New targets and treatment strategies,powered by the understanding of disease mechanisms,the discovery of new genes,and the proposal of new classifications,are continuously applied in clinical practice and research.This article reviews the progress in the treatment of SAIDs in the past three years,introduces the updates in SAIDs treatment,and aims to promote the recognition,diagnosis,treatment,and research of such diseases in the future.
国家科技期刊平台
NSTL
万方数据
