非炎症小体病诊治进展
Progress in diagnosis and treatment of non-inflammasom-apathies
黄艳艳 1杨军1
作者信息
- 1. 深圳市儿童医院风湿免疫科,广东 深圳 518038
- 折叠
摘要
非炎症小体病是自身炎症性疾病中的一大类疾病,其囊括病种数较多,临床表现复杂多样.多数临床表现为反复发热、皮疹、关节炎症、眼部炎症,急性期炎症指标升高,根据临床线索需进一步完善基因检查明确诊断.目前尚无明确的非炎症小体病治疗指南,激素、非甾体类抗炎药、多种免疫抑制药物及生物制剂均有应用,但疗效各异.文章旨在介绍常见非炎症小体病发病机制、临床表现及诊治经验,以期提高临床医生对该类疾病认知.
Abstract
Non-inflammasomapathies is a group of autoinf-lammatory diseases.The clinical manifestations are complex.The common clinical manifestations are repeated fever,rash,arthritis,eye inflammation,and increased inflammatory protein in the acute phase.Genetic examination should be further improved to confirm the diagnosis.There are no guidelines for the treatment of non-inflammasomapathies.Glucocorticoids,non-steroidal anti-inflammatory drugs,immunosuppressives and biological agents have been applied,but the efficacy is different.In this review,the pathogenesis,clinical manifestations,diagnosis and treatment experience were discussed,so as to provide new insights for the understanding of these diseases.
关键词
自身炎症性疾病/非炎症小体病/发热Key words
autoinflammatory diseases/non-inflammasoma-pathies/fever引用本文复制引用
基金项目
国家重点研发计划(2021YFC2702001)
广东省高水平临床重点专科建设项目(SZGSP012)
出版年
2024
国家科技期刊平台
NSTL
万方数据