Neurological damage of systemic autoinflammatory diseases
Systemic autoinflammatory diseases(SAIDs)is a group of diseases caused by systemic inflammatory response due to dysfunction of the innate immune system.Due to genetic mutations causing changes in the encoded protein,it is also known as hereditary autoinflammatory disease.SAIDs have a wide variety of types,clinical manifestations and pathogenesis.It is classified into different types based on its clinical characteristics and pathogenesis.These diseases are more common in childhood and can affect multiple systems throughout the body.Among them,neurological damage is an important factor affecting the clinical prognosis of patients.Due to insufficient understanding of SAIDs,neurological damage often presents as non-specific symptoms and is easily misdiagnosed.Early identification,diagnosis,and initiation of treatment are of great significance for improving clinical prognosis.