Kidney injury in systemic autoinflammatory diseases
The kidney is a major target organ of systemic autoinflammatory diseases.The clinical manifestations vary from proteinuria,nephrotic syndrome,and renal insufficiency which may end up requiring renal failure or death.The pathogenetic mechanisms are likewise quite diverse,ranging from amyloidosis caused by persistent or recurrent inflammation to inflammasome activation-mediated vasculitis/vasculopathy and several other uncommon types of glomerulonephritis.It is critical to increase the understanding and early identification of autoinflammatory diseases,as well as acquire pathology in time when renal injury occurs,to enhance disease recovery and prognosis.
systemic autoinflammatory diseaseskidney injuryrenal amyloidosisamyloid A amyloidosis
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