系统性自身炎症性疾病的肾脏损伤
Kidney injury in systemic autoinflammatory diseases
王大海 1常红1
作者信息
- 1. 青岛大学附属医院儿童肾脏风湿免疫科,山东青岛 266003
- 折叠
摘要
肾脏是系统性自身炎症性疾病较易累及的靶器官之一,临床可表现为蛋白尿、肾病综合征、肾功能不全,如延误诊断和治疗可导致肾衰竭甚至死亡.发病机制包括炎症持续存在或反复发生导致的肾淀粉样变性和基于炎症小体激活的肾血管炎,此外还有更罕见的其他各种类型的肾小球肾炎.提高对自身炎症性疾病的认识和早期识别,出现肾脏损伤时及时获取病理,对疾病的早期恢复和改善预后至关重要.
Abstract
The kidney is a major target organ of systemic autoinflammatory diseases.The clinical manifestations vary from proteinuria,nephrotic syndrome,and renal insufficiency which may end up requiring renal failure or death.The pathogenetic mechanisms are likewise quite diverse,ranging from amyloidosis caused by persistent or recurrent inflammation to inflammasome activation-mediated vasculitis/vasculopathy and several other uncommon types of glomerulonephritis.It is critical to increase the understanding and early identification of autoinflammatory diseases,as well as acquire pathology in time when renal injury occurs,to enhance disease recovery and prognosis.
关键词
系统性自身炎症性疾病/肾脏损伤/肾淀粉样变性病/AA淀粉样变性Key words
systemic autoinflammatory diseases/kidney injury/renal amyloidosis/amyloid A amyloidosis引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据