Sepsis is a common cause of death in children.Immune inflammatory response is a key mechanism in the pathogenesis of sepsis.Sepsis with different stages of disease,excessive proinflammatory compensatory anti-inflammatory response and reaction causes the immune system balance,eventually leading to immune.Comprehensive understanding of children sepsis immune inflammatory response and development,attaches great importance to the children of sepsis immune dynamic evaluation,is advantageous to the precise treatment and individualized treatment,diagnosis and treatment to improve children's sepsis,improve disease and after,and to reduce the financial burden of medical purpose.