Effectiveness and tolerability of adjunctive perampanel in children with epilepsy:A single center retrospective study
Objective To investigate the 6-month efficacy,safety and tolerability of adjunctive perampanel in children with epilepsy and compare those differences in older(≥7)and younger(＜7)age groups.Methods Children who were diagnosed with epilepsy and treated with perampanel in Wuhan Chlidren's Hospital from June 2020 to January 2022 were included in this retrospective study.Effectiveness,safety and tolerability of perampanel between different age goups at 6 months were compared.The single or multivariate logistic regression analysis were used to analyze baseline factors affecting efficacy in duration of epilepsy,number of ASMs,final daily dose of perampanel,baseline seizure frequency and structural etiology.Results A total of 128 children were enrolled.99 children still were treated with perampanel at 6 months,The retention rate were 77.3％(99/128),and 50％responder rate and seizure freedom rate were 47.6(61/128)and 20.3％(26/128).No significant differences in effectiveness were found between two age groups.Adverse events were 22.7％(29/128).No correlation was found between the efficacy and intellectual disability,duration of epilepsy,number of ASMs,final daily dose of perampanel,baseline seizure frequency and structural etiology.Conclusion Perampanel was efficacious and generally well-tolerated as an add-on treatment for children.No differences were found between age group and no effectiveness-related factors were found.
国家科技期刊平台
NSTL
万方数据
