Research advances in the pathogenesis of inherited hyperammonemia
Ammonia plays a crucial role in biosynthesis and metabolism.Elevated blood ammonia levels can lead to irreversible damage,particularly to the central nervous system.In children,the most common causes of hyperammonemia are liver failure and inherited metabolic disorders.Inherited hyperammonemia results from defects in enzymes involved in the urea cycle or related metabolic pathways.This article systematically reviews the pathogenesis of inherited hyperammonemia and its association with mitochondrial function,and investigate the role of mitochondrial function in inherited hyperammonemia,which may provide ideas for the development of new drugs.
国家科技期刊平台
NSTL
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