儿童和青少年1型糖尿病胰岛细胞功能评估方法
Assessment of islet cell function in children and adolescents with type 1 diabetes
尤凤妍 1孙妍 2徐海 3韩林岐 4魏志强3
作者信息
- 1. 山东第二医科大学,山东潍坊 261000;阳光融和医院,山东潍坊 261000
- 2. 山东第一医科大学附属省立医院儿科,山东济南 250021
- 3. 山东第二医科大学,山东潍坊 261000
- 4. 山东中医药大学,山东济南 250021
- 折叠
摘要
1型糖尿病的发病主要源于T细胞介导的胰岛细胞特异性免疫损伤,具有C肽和胰岛素降低、糖尿病相关抗体阳性、糖尿病酮症酸中毒常见、依赖胰岛素治疗等特征.临床实践中部分糖尿病患儿特征不典型,糖尿病分型困难,胰岛β细胞功能的评估为分型提供重要依据.该文通过汇总β细胞功能评估方法的比较,包括葡萄糖耐量试验(OGTT)、血清C肽、胰岛素生成指数等,以期提高对儿童青少年1型糖尿病患儿残存的胰岛功能的评估能力,提升糖尿病患儿的鉴别水平,更好地指导儿童青少年1型糖尿病患儿的治疗和随访.
Abstract
Type 1 diabetes is mainly caused by T cell-mediated islet cell-specific immune damage.The characteristics include decreased C-peptide and insulin,positive diabetes-related antibodies,more diabetic ketoacidosis,and dependence on insulin therapy.In clinical practice it is difficult to classify type 1 and type 2 diabetes in some children and adolescents due to atypical clinical features.The assessment of islet β cell function provides an important evidence for the classification.This article summarizes the evaluation methods of islet β cell function,including oral glucose tolerance test,serum C-peptide and insulin production index,aiming to improve the ability to evaluate residual islet function in patients with type 1 diabetes,increase the level in identifying diabetes children,and provide better guidance to the treatment and follow-up of children with type 1 diabetes.
关键词
1型糖尿病/儿童青少年/胰岛细胞功能/葡萄糖耐量试验/β细胞稳态评估模型Key words
type 1 diabetes/children and adolescents/islet cell function/glucose tolerance test/β-cell homeostasis assessment model引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据