Effect of assisted reproductive technology conception on the risk of premature delivery in twin pregnancy
Objective To investigate the effect of assisted reproductive technology(ART)conception on the risk of pre-mature delivery in dichorionic-diamniotic twin pregnancy.Methods A retrospective study was preformed in 2501 wom-en with dichorionic-diamniotic(DCDA)twin pregnancies who delivered at least one live birth(n=2501)in the fourth Hospital of Shijiazhuang from January 2018 to December 2022.The incidence of preterm birth and premature adverse out-come events were compared between the natural conception group(n=1223)and the ART group(1278).Results The in-cidence of preterm birth in ART group was significantly higher than that in natural conception group(52.35％vs.48.24％,P＜0.05).The incidence of early preterm birth(28 to 31+6 weeks of gestation)was significantly higher in the ART group than in the natural conception group(13.75％vs.7.80％),while the incidence of late preterm birth(34 to 36+6 weeks of gestation)was lower than in the natural conception group(71.15％vs 77.80％,P＜0.05).The mean age and proportion of primiparous women in the ART group were higher than those in the natural conception group,and the pregnancy frequency was lower than that in the natural conception group,the difference being statistically significant(P＜0.05),and the incidence of spontaneous preterm birth in the ART group was higher than that in the natural conception group.Compared with the natural conception group,the premature infants in ART group had lower birth weight,higher rate of admission to NICU,and longer hospital stay(P＜0.05).However,there were no statistically significant differences in the incidence of intrauterine death of one twin,premature infant mortality,or premature infant as-phyxia(P＞0.05).Conclusions Compared with natu-ral conception,ART conception can significantly increase the incidence of preterm birth in double chorionic twin preg-nancies,especially the incidence of early preterm birth before 32 weeks of gestation and the incidence of spontaneous pre-term birth.ART preterm babies have lower birth weight,higher rate of admission to NICU,and longer hospital stay.Therefore,health care and management during pregnancy should be strengthened for ART pregnant women with DCDA twins,to actively prevent the occurrence of early preterm birth.
万方数据
维普
