Analysis of the factors affecting the high-grade and low-grade squamous cervical intrapithelial neoplasia
Objective To explore the effect of high-risk human papillomavirus(HR-HPV)infection and vaginal micro-ecology on cervical intraepithelial neoplasia(CIN).Methods Totally 124 CIN patients admitted to Jiangnan Hospital affiliated to Zhejiang University of Traditional Chinese Medicine from January 2019 to January 2023 were selected as the experimental group.They were divided into two groups based on the level of cervical lesions:62 cases in the high-grade squamous intraepithelial neoplasia(HSIL)group and 65 cases in the low-grade squamous intraepithelial neoplasia(LSIL)group,and 107 healthy individuals with normal cervix who underwent routine physical examinations(vaginal se-cretion microbiota and human papillomavirus genotype testing)during the same period were selected as the control group.The clinical data vaginal and inflammatory cytokine level between the two groups were compared,and a logistic regression model was used to analyze the correlation between HR-HPV infection and vaginal microbiota.Results There were significant differences among the 3 groups in HPV infection,BV,VVC,TNF-α,IL-2,IL-4,IFN-γ,age at first sex at less than 20 years,age of first gestation＜20 years,HPV infection,abnormal vaginal microecology(BV,VVC)and abnormal flora diversity(P＜0.05).The single factors(P＜0.05)affecting the occurrence of HSIL and LSIL were again included in the logistic regression analysis to obtain the multifactorial indicators affecting HSIL and LSIL.See Table 2.We found that HPV infection and abnormal vaginal microecology(BV,VVC)were independent risk factors for the occurrence of LSIL(P＜0.05);age at first sex,HPV infection,abnormal flora diversity,vaginal microecology(BV,TV,VVC)and WBC were independent risk factors affecting the occurrence of HSIL(P＜0.05).Conclu-sions HPV infection,abnormal expression of inflam-matory factors,and abnormal vaginal microecology are risk factors affecting the occurrence of LSIL.while HPV infection,age at first sexual life,abnormal flora diversity and white blood cell count are risk factors for the occurrence of HSIL patients.
cervical intraepithelial neoplasiahigh-risk human papillomavirusvaginal microecology
万方数据
维普
