The influence of cervico-vaginal microbiota on cervical HPV infection and the development of lesions
Cervico-vaginal microbiota(CVMB)plays a crucial role in female reproductive health and is closely involved in the entire pathological process of persistent infection of human papillomavirus(HPV),cervical intraepithelial neoplasia,and invasive cervical cancer.This article provides a comprehensive review of the relationship between the structure and classifi-cation cervical-vaginal microbiota and HPV infection,as well as cervical lesions.It focuses on the possible mechanisms linking key bacterial species in CVMB to HPV infection and the development of cervical lesions.The vaginitis caused by imbalances of CVMB are also highlighted as a influencing factor.Additionally,the potential of interventions targeting CVMB for promote HPV virus clearance is discussed.However,there is currently a lack of strong medical evidence derived from clinical trials.Therefore,further well-designed studies are needed to comprehend the interaction mechanisms between CVMB and HPV infection and cervical lesions,as well as to elucidate the role of CVMB as a potential biomarker for predicting,diag-nosing,and treating HPV infection and related dis-eases.This will support personalized diagnosis and treatment,contributing to cervical cancer prevention and treatment.
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