育龄期子宫内膜息肉患者阴道微生态分析
Analysis of vaginal microecology in reproductive age endometrial polyps patients
张金甜 1王刚 1闫晔 1田丽娜 1王平 1田文艳 1赵雪 1张慧英 1薛凤霞1
作者信息
- 1. 天津医科大学总医院妇产科天津市女性生殖健康与优生重点实验室,天津 300052
- 折叠
摘要
目的 探讨育龄期子宫内膜息肉(endometrial polyps,EPs)患者阴道微生态特点.方法 回顾性分析2017年1月1日至2020年12月31日就诊于天津医科大学总医院的224例经宫腔镜手术病理诊断为EPs的育龄期患者(EPs组),以同期448例健康查体育龄期女性为对照组,比较两组人群阴道微生态指标差异.并将224例EPs患者分为阴道微生态正常组及异常组,回顾性分析两组患者的临床特征.结果 (1)育龄期EPs患者阴道炎发生率高于健康查体女性(33.9％vs.19.0％,P＜0.001),阴道微生态正常比例低于健康查体女性(42.4％vs.60.7％,P＜0.001);排除确诊阴道炎的患者外,EPs患者阴道分泌物pH值异常、乳杆菌分级Ⅱb～Ⅲ级的发生率均高于健康查体女性(23.6％vs.6.6％,P＜0.001;12.2％vs.6.6％,P=0.038).(2)224例EPs患者中,阴道微生态异常组异常子宫出血(abnormal uterine bleeding,AUB)、不孕及合并子宫颈息肉的发生率均高于阴道微生态正常组(分别为74.6％vs.61.7％,P=0.039;28.5％vs.16.0％,P=0.029;25.4％vs.13.8％,P=0.035),差异有统计学意义.结论 与健康女性相比,育龄期EPs患者阴道微生态异常的发生率更高;对于EPs患者应注重阴道微生态评价.
Abstract
Objective To explore the vaginal microecology characteristics in patients with endometrial polyps of repro-ductive age.Methods A total of 224 patients of reproductive age diagnosed with endometrial polyps through hystero-scopic surgery in Tianjin Medical University General Hospital from January 1,2017 to December 31,2020 were selected as the study group,and 448 healthy women during the same period were selected as the control group,and the differences in vaginal microecology between the two groups were compared.A total of 224 patients with endometrial polyps were di-vided into normal vaginal microecology group and abnormal vaginal microecology group,and the clinical characteristics of the two groups were retrospectively analyzed.Results(1)The incidence of vaginitis in patients with endometrial pol-yps group was higher than that in healthy women(33.9％vs.19.0％,P＜0.001),and the incidence of the normal propor-tion of viginal microewloy in patients with endometrial polyps group was lower than that in healty women(42.4％vs.60.7％,P＜0.001).Excluding patients with confirmed vaginitis,the incidence of abnormal pH value of vaginal discharge and Lactobacillus grade Ⅱb～Ⅲ.in patients with endometrial polyps was higher than that in healthy control(23.6％vs.6.6％,P＜0.001;12.2％vs.6.6％,P=0.038).(2)Among the 224 patients with endometrial polyps,the incidence of ab-normal uterine bleeding,infertility and cervical polyps in the abnormal vaginal microecology group was higher than that in the normal vaginal microecology group(74.6％vs.61.7％,P=0.039;28.5％vs.16％,P=0.029;25.4％vs.13.8％,P=0.035),and the difference was statistically significant.Conclusion Compared with healthy control,reproductive age en-dometrial polyps group have a higher incidence of vaginal microbiota abnormalities,and Clinician should paid attention to the evaluation of vaginal microecology.
关键词
子宫内膜息肉/阴道微生态/临床特征Key words
endometrial polyps/vaginal microecology/clinical characteristics引用本文复制引用
基金项目
天津市科技计划项目(21JCYBJC01080)
天津市卫生健康科技项目(TJWJ2022XK003)
天津市医学重点学科(专科)建设项目(TJYXZDXK-031A)
出版年
2024
国家科技期刊平台
NSTL
万方数据