Clinical study on the association between abnormal vaginal microbiota and high-risk HPV infection in the fe-male genital tract
Objective To investigate the correlation between high-risk human papillomavirus(HPV)infection and abnor-malities in vaginal microbiota.Methods Clinical data from 17 383 patients undergoing vaginal microecology testing and 22 221 patients undergoing high-risk HPV typing at the Gynecology Outpatient Department of The First Affiliated Hospi-tal of University of Science and Technology of China from July 2022 to June 2023 were analyzed.Results Among the 17383 patients,98.80％(17 175/17 383)exhibited microecological imbalance or inflammatory infection,including bacterial vaginosis(BV)in 1923 cases(11.20％),aerobic vaginitis(AV)in 1124 cases(6.54％),vulvovaginal candidiasis(VVC)in 1,468 cases(8.54％),and trichomonal vaginitis(TV)in 7 cases(0.04％).The ages of patients with BV and AV displayed a"bi-modal"distribution,while VVC patients showed a"unimodal"distribution.Among the 22 221 HPV typing patients,the infec-tion rate was 24.00％(5334/22 221),with a"bimodal"age distribution;the predominant subtypes were HPV 52,16,and 58(with case number being 1445,867 and 860,respectively).BV infection(Nugent score≥4),positive clue cell,elevated pH,and positive sialic anhydrase were positively associated with HPV infection,respectively(OR=1.22,95％CI 1.01-1.48,P=0.037,Φc=0.039;OR=1.85,95％CI 1.48-2.32,P＜0.001,Φc=0.101;OR=1.21,95％CI 1.00-1.46,P=0.047,Φ=0.037;OR=1.80,95％CI 1.43-2.26,P＜0.001,Φc=0.095).Conclusion BV infection,positive clue cells,ele-vated vaginal pH and positive sialic anhydrase are posi-tively associated with high-risk HPV infection.
国家科技期刊平台
NSTL
万方数据
