Hepatoprotective Effect of Silibinin Combined with Polyene Phosphatidylcholine in Chemotherapy of Active Pulmonary Tuberculosis Patients
Objective To explore the hepatoprotective effect of silibinin combined with polyene phosphatidylcholine during chemotherapy in patients with active pulmonary tuberculosis(APT).Methods Fifty APT patients admitted to Fuxin Infectious Disease Hospital from January 2020 to December 2022 were randomly divided into a control group and an observation group,with 25 cases in each group.Both groups of patients received liver protection treatment during chemotherapy.The control group was treated with polyene phosphatidylcholine.The observation group added silibinin on this basis.The indicators of liver function,inflammatory factors,and oxidative stress in two groups were compared after 3 months of treatment.Results After treatment,the levels of alanine aminotransferase,aspartate aminotransferase,total bilirubin gamma-glutamyl transferase,alkaline phosphatase,tumor necrosis factor-α,interleukin-1β,interleukin-2,interleukin-6,interleukin-17,malondialdehyde,and nitric oxide in the observation group were significantly lower than those in the control group(P<0.05).The levels of superoxide dismutase,reduced glutathione and ceruloplasmin in the observation group were significantly higher than those in the control group(P<0.05).Conclusion The combination of silibinin and polyene phosphatidylcholine can enhance liver protection,which may be related to regulating oxidative stress and inflammatory response.
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