肝移植术后早期细菌与真菌感染的病原体分布特点及危险因素分析
Pathogen Distribution Characteristics and Risk Factors Analysis of Early Bacterial and Fungal Infections after Liver Transplantation
曲燕燕1
作者信息
- 1. 100012 北京,航空总医院感染疾病科
- 折叠
摘要
目的 探讨肝移植术患者术后早期细菌与真菌感染的病原体分布特点及危险因素.方法 选取2015年1月—2018年12月航空总医院收治的200例肝移植术患者,统计细菌与真菌感染的病原体分布,并对感染发生情况进行单因素与Logistic多因素回归分析.结果 200例肝移植术患者中,143例(178株)发生细菌或真菌感染,早期感染发生率为71.50%(143/200);G-杆菌(占48.31%)在病原菌中占有优势,其次是G+球菌(占32.02%);感染组术前2个月内感染、术后气管插管≥48 h、再次手术患者比例高于非感染组次,差异有统计学意义(P＜0.05).多因素Logistic分析结果显示,术前2个月内感染(OR=3.674)、术后气管插管≥48 h(OR=2.145)、再次手术(OR=1.895)是肝移植术后患者细菌与真菌感染发生的独立危险因素(P＜0.05).结论 肝移植患者术后早期细菌与真菌感染发生率较高,G-杆菌为最常见病原体;术前2个月内感染、术后气管插管≥48 h及再次手术会对感染发生造成影响.
Abstract
Objective To explore the pathogen distribution characteristics and risk factors of early postoperative bacterial and fungal infections in liver transplant patients.Methods Two hundred liver transplant patients admitted to the Aviation General Hospital from January 2015 to December 2018 were selected,and the distribution of pathogens causing bacterial and fungal infections was statistically analyzed.Univariate and logistic multiple regression analyses were performed on the incidence of infections.Results Among the 200 liver transplant patients,143 cases(178 strains)developed bacterial or fungal infections,with an early infection rate of 71.50%.In those 48.31%of G-bacteria have an advantage in pathogenic bacteria,followed by 32.02%of G+cocci.The infection group had a higher proportion of patients with infection within 2 months before surgery,tracheal intubation≥48 hours after surgery,and reoperation compared to the non infection group(P<0.05).The results of logistic multivariate analysis showed that infection within 2 months before surgery(OR=3.674),postoperative tracheal intubation≥48 hours(OR=2.145),and reoperation(OR=1.895)were independent risk factors for bacterial and fungal infections in liver transplant patients(P<0.05).Conclusion Early postoperative bacterial and fungal infections are more common in liver transplant patients,with G-bacilli being the most common pathogen;Infection within 2 months before surgery,tracheal intubation≥48 hours after surgery,and reoperation can have an impact on the occurrence of infection.
关键词
肝移植术/病原体/细菌感染/真菌感染/危险因素Key words
Liver Transplantation Surgery/Pathogens/Bacterial Infection/Fungal Infection/Risk Factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据