摘要
目的 探讨中医定向药透对气阴两虚型Ⅲ期糖尿病肾病患者的临床疗效及安全性.方法 选择2018年6月—2023年6月天津医科大学第二医院收治的80例气阴两虚型Ⅲ期糖尿病肾病患者,随机分为对照组和观察组各40例.对照组接受西药常规治疗,观察组在其基础上接受中医定向药透.比较两组患者的中医证候积分、肾功能、血糖、炎症指标改善情况及不良反应发生情况.结果 治疗后,观察组咽干口燥、头晕多梦、肢体麻木、气短懒言、神疲乏力及尿浊的中医证候评分低于对照组,差异有统计学意义(P＜0.05);观察组尿素氮、β2微球蛋白、血肌酐、24 h尿蛋白、尿白蛋白排泄率、糖化血红蛋白、餐后2 h血糖、空腹血糖、糖化血清蛋白、血清转化因子β1、肿瘤坏死因子-α、白细胞介素-17低于对照组;而空腹C肽高于对照组,差异有统计学意义(P＜0.05).观察组不良反应的发生率均低于对照组,差异有统计学意义(P＜0.05).结论 中医定向药透治疗气阴两虚型Ⅲ期糖尿病肾病疗效确切,能够改善中医症候,调节肾功能、血糖和炎症反应,且安全性较好.
Abstract
Objective To explore the clinical efficacy and safety of Chinese medicine directed penetration in the treatment of patients with qi-yin deficiency Stage Ⅲ diabetic nephropathy.Methods From June 2018 to June 2023,80 patients with qi-yin deficiency Stage Ⅲ diabetic nephropathy admitted to the Second Hospital of Tianjin Medical University were randomly divided into a control group and an observation group,with 40 patients in each group.The control group received conventional Western medicine treatment,while the observation group received targeted traditional Chinese medicine treatment addtionally.The improvement of traditional Chinese medicine syndrome scores,renal function,blood glucose,inflammation indicators,and incidence of adverse reactions between two groups of patients were compared.Results After treatment,the traditional Chinese medicine syndrome scores of dry throat and mouth,dizziness and frequent dreams,limb numbness,shortness of breath and lazy speech,fatigue and urinary turbidity in the observation group were lower than those in the control group(P<0.05).The observation group showed lower urea nitrogen,β2-microglobulin,serum creatinine,24-hour urinary protein,urinary albumin excretion rate,glycated hemoglobin,2-hour postprandial blood glucose,fasting blood glucose,glycated serum protein,serum transforming factor β1,tumor necrosis factor-α,and interleukin-17,and higher fasting C-peptide compared to the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Targeted drug penetration of traditional Chinese medicine is effective in the treatment of qi-yin deficiency Stage Ⅲ diabetic nephropathy,which could improve the symptoms of traditional Chinese medicine,regulate renal function,blood sugar and inflammatory reaction,and has good safety.
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