Objective:To study the necessity and importance of operation maintenance management mode of Medical Cloud Project, and put forward the new pattern for operation maintenance management of digital hospital under the cloud computing conditions. Method: Business structure change and challenge after introduction of cloud computing by Medical Cloud Project are analyzed and implemented. Operation maintenance management requirements under the cloud computing conditions are studied. Solutions are provided. Results:According to the operation maintenance management requirements of cloud computing, the organization structure of operation maintenance management, various operation maintenance positions and responsibilities of cloud platform, operation maintenance boundary between them are defined. Combined with the corresponding operation maintenance rules and regulations and management process, it is restricted so as to realize an efficient and standard cloud platform operation maintenance management system. Conclusion:During the advancement of Medical Cloud Project, effect of cloud computing shall be given full play to, and operation maintenance management model of cloud computing shall be established.