首页|A new biflavone glucoside from the roots of Stellera chamaejasme

A new biflavone glucoside from the roots of Stellera chamaejasme

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The present study investigated the chemical constituents of the roots of Stellera chamaejasme (Thymelaeaceae).One new biflavone glucoside (1),along with other thirteen known compounds (2-14),was isolated by repeated column chromatographic methods and theit structures were elucidated on the basis of spectral analyses.The cytotoxic activities of selected compounds were evaluated against four human cancer cell lines (A549,BEL-7402,HCT-116,and MDA-MB-231) by the SRB assay method.Compound 9 showed remarkable cytotoxicity against BEL-7402 with IC50 value being 0.65 μg·mL-1;compounds 7,8,and 12 exhibited significant cytotoxic activity against A549 with IC50 values being 2.38,1.57,and 2.35 μg.mL-1,respectively.

Stellera chamaejasmeThymelaeaceaeBiflavone glucosideCytotoxicity

CHEN Wei、LUO Xiao-Hua、WANG Zhuo、ZHANG Ying-Ying、LIU Li-Ping、WANG Hong-Bing

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School of Life Sciences and Technology, Tongji University, Shanghai 200092, China

This work was supported by the National Natural Science Foundation of ChinaThis work was supported by the National Natural Science Foundation of ChinaFundamental Research Funds for the Central Universities

81001369311703272000219078

2015

10.3724/SP.J.1009.2015.00550

中国天然药物
中国药科大学,中国药学会

中国天然药物

CSTPCDCSCD
影响因子：0.859
ISSN：1672-3651
年,卷(期)：2015.13(7)
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