首页|A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena

A new γ-alkylated-γ-butyrolactone from the roots of Solanum melongena

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A new γ-alkylated-γ-butyrolactone,named melongenolide A (1),along with nine known compounds were obtained from the roots of Solanum melongena,and their structures were identified as melongenolide A (1),(+)-syringaresinol (2),(+)-lyoniresinol (3),5,5'-dimethoxy lariciresinol (4),(+)-(7R,8R)-4-hydroxy-3,3',5'-trimethoxy-8',9'-dinor-8,4'-oxyneoligna-7,9-diol-7'-aldehyde (5),kaempferol-3-O-(2",6"-di-O-p-trans-coumaroyl)-β-glucoside (6),arjunolic acid (7),vanillic acid (8),scoparone (9),and β-sitosterol (10).Compounds 2,6,and 7 showed potent inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW 264.7 macrophages,with IC5o values being 5.62 ± 0.86,11.47 ± 0.98,and 27.75 ± 1.26 μmol-L-l,respectively.

SolanaceaeSolanum melongenaγ-Alkylated-γ-butyrolactoneMelongenolide AAnti-inflammation

SUN Jing、HUO Hui-Xia、HUANG Zheng、ZHANG Jing、LI Jun、TU Peng-Fei

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Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China

Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in UniversityProject of Standards Improvement of TCM for CP2015TCM support project from Ministry of Industry and Information Technology of China (to LI J.)National Key Technology R&D Program "New Drug Innovation" of China

NCET-13-0693to LI J2013ZX09402201001

2015

10.3724/SP.J.1009.2015.00699

中国天然药物
中国药科大学,中国药学会

中国天然药物

CSTPCDCSCD
影响因子：0.859
ISSN：1672-3651
年,卷(期)：2015.13(9)
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