首页|Anti-neuro-inflammatory effects of Nardostachys chinensis in lipopolysaccharide-and lipoteichoic acid-stimulated microglial cells

Anti-neuro-inflammatory effects of Nardostachys chinensis in lipopolysaccharide-and lipoteichoic acid-stimulated microglial cells

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Excessive microglial cell activation is related to the progression of chronic neuro-inflammatory disorders.Heme oxygenase-1 (HO-1) expression mediated by the NFE2-related factor (Nrf-2) pathway is a key regulator of neuro-inflammation.Nardostachys chinensis is used as an anti-malarial,anti-nociceptive,and neurotrophic treatment in traditional Asian medicines.In the present study,we examined the effects of an ethyl acetate extract ofN.chinensis (EN) on the anti-neuro-inflammatory effects mediated by HO-1 up-regulation in Salmonella lipopolysaccharide (LPS)-or Staphylococcus aureus lipoteichoic acid (LTA)-stimulated BV2 microglial cells.Our results indicated that EN suppressed pro-inflammatory cytokine production and induced HO-1 transcription and translation through Nrf-2/antioxidant response element (ARE) signaling.EN markedly inhibited LPS-and LTA-induced activation of nuclear factor-kappa B (NF-κB) as well as phosphorylation of mitogen-activated protein kinases (MAPKs) and signal transducer and activator of transcription (STAT).Furthermore,EN protected hippocampal HT22 cells from indirect neuronal toxicity mediated by LPS-and LTA-treated microglial cells.These results suggested that EN impairs LPS-and LTA-induced neuro-inflammatory responses in microglial cells and confers protection against indirect neuronal damage to HT22 cells.In conclusion,our findings indicate that EN could be used as a natural anti-neuro-inflammatory and neuroprotective agent.

Nardostachys chinensisAnti-inflammationLipopolysaccharideLipoteichoic acidHeme oxygenase-1

Sun Young Park、Young Hun Kim、Geuntae Park

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Bio-IT Fusion Technology Research Institute, Pusan National University, Busan, Korea

Department of Nanomaterials Engineering, Pusan National University, Busan, Korea

Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education,SMinistry of Trade,Industry,and Energy (MOTIE)Korea Institute for Advancement of Technology (KIAT) through the Promoting Regional Specialized Industry Program

2015R1D1A1A01059450R0004422

2016

10.3724/SP.J.1009.2016.00343

中国天然药物
中国药科大学,中国药学会

中国天然药物

CSTPCDCSCD
影响因子：0.859
ISSN：1672-3651
年,卷(期)：2016.14(5)
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