首页|Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)

Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)

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The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional Chinese herbal medicine.In the current study,the antiproliferative constituents of giant taro were investigated and six new(1-6)and four known piperidine alkaloids(7-10)were isolated from its rhizomes.Their chemical structures and absolute configurations were elucidated using various spectroscopic methods and the Mosher ester method.The isolated alkaloids were screened for the antiprolifer-ative activity through MTT assay.The results indicated that piperidine alkaloids exerted potential antiproliferative activity against HepG2,AGS and MCF-7 tumor cells.Further researches showed that compounds 3-5 dose-dependently decreased the colony forma-tion rate and induced the apoptosis of AGS cells,while compound 4 induced AGS cell death via the proapoptotic pathway.This study demonstrates that the piperidine alkaloids isolated from giant taro exhibit significant antitumor activity,which provides phytochemical evidence for further development and utilization.

Giant taroAlocasia macrorrhizaPiperidine alkaloidsAntiproliferativeApoptosis

GAO Wei、WANG Yi、WANG Ru、WANG Yi-Hai、XU Jing-Wen、HE Xiang-Jiu

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School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006,China

Guangdong Engineering Research Center for Lead Compounds&Drug Discovery,Guangzhou 510006,China

National Natur-al Science Foundation of ChinaGuangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2017)Pearl River S&T Nova Program of Guang-zhou

82173698201806010169

2022

10.1016/S1875-5364(22)60165-1

中国天然药物
中国药科大学,中国药学会

中国天然药物

CSTPCDCSCDSCI
影响因子：0.859
ISSN：1672-3651
年,卷(期)：2022.20(7)
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