中国天然药物2025,Vol.23Issue(1) :31-42.DOI:10.1016/S1875-5364(25)60800-4

Recent advances,strategies,and future perspectives of peptide-based drugs in clinical applications

Qimeng Yang Zhipeng Hu Hongyu Jiang Jialing Wang Han Han Wei Shi Hai Qian
中国天然药物2025,Vol.23Issue(1) :31-42.DOI:10.1016/S1875-5364(25)60800-4

Recent advances,strategies,and future perspectives of peptide-based drugs in clinical applications

Qimeng Yang 1Zhipeng Hu 1Hongyu Jiang 1Jialing Wang 1Han Han 1Wei Shi 1Hai Qian2
扫码查看

作者信息

  • 1. Centre of Drug Discovery,State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China
  • 2. Centre of Drug Discovery,State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China;Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease,China Pharmaceutical University,Nanjing 210009,China
  • 折叠

Abstract

Peptide-based therapies have attracted considerable interest in the treatment of cancer,dia-betes,bacterial infections,and neurodegenerative diseases due to their promising therapeut-ic properties and enhanced safety profiles.This review provides a comprehensive overview of the major trends in peptide drug discovery and development,emphasizing preclinical strategies aimed at improving peptide stability,specificity,and pharmacokinetic properties.It assesses the current applications and challenges of peptide-based drugs in these diseases,il-lustrating the pharmaceutical areas where peptide-based drugs demonstrate significant po-tential.Furthermore,this review analyzes the obstacles that must be overcome in the future,aiming to provide valuable insights and references for the continued advancement of peptide-based drugs.

Key words

Peptide-based drugs/Oncology/Diabetes/Antimicrobial peptides/Neurodegenerative diseases

引用本文复制引用

出版年

2025
中国天然药物
中国药科大学,中国药学会

中国天然药物

CSCD
影响因子:0.859
ISSN:1672-3651
段落导航相关论文