首页|Recent advances,strategies,and future perspectives of peptide-based drugs in clinical applications

Recent advances,strategies,and future perspectives of peptide-based drugs in clinical applications

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Peptide-based therapies have attracted considerable interest in the treatment of cancer,dia-betes,bacterial infections,and neurodegenerative diseases due to their promising therapeut-ic properties and enhanced safety profiles.This review provides a comprehensive overview of the major trends in peptide drug discovery and development,emphasizing preclinical strategies aimed at improving peptide stability,specificity,and pharmacokinetic properties.It assesses the current applications and challenges of peptide-based drugs in these diseases,il-lustrating the pharmaceutical areas where peptide-based drugs demonstrate significant po-tential.Furthermore,this review analyzes the obstacles that must be overcome in the future,aiming to provide valuable insights and references for the continued advancement of peptide-based drugs.

Peptide-based drugsOncologyDiabetesAntimicrobial peptidesNeurodegenerative diseases

Qimeng Yang、Zhipeng Hu、Hongyu Jiang、Jialing Wang、Han Han、Wei Shi、Hai Qian

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Centre of Drug Discovery,State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China

Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease,China Pharmaceutical University,Nanjing 210009,China

2025

中国天然药物
中国药科大学,中国药学会

中国天然药物

影响因子:0.859
ISSN:1672-3651
年,卷(期):2025.23(1)