Amoenucles A-F,novel nucleoside derivatives with TNF-α inhibitory activities from Aspergillus amoenus TJ507

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外文摘要：Amoenucles A-F(1-6),six previously undescribed nucleoside derivatives,and two known analogs(7 and 8)were isolated from the culture of Aspergillus amoenus TJ507.Their struc-tures were elucidated through spectroscopic analysis,single-crystal X-ray crystallography,and chemical reactions.Notably,3 and 4 represent the first reported instances of nucleosides with an attached pyrrole moiety.Of particular significance,the absolute configuration of the sugar moiety of 1-4 was determined using nuclear magnetic resonance(NMR),electric circu-lar dichroism(ECD)calculations,and a hydrolysis reaction,presenting a potentially valuable method for confirming nucleoside structures.Furthermore,1,2,and 5-8 exhibited potential tumor necrosis factor α(TNF-α)inhibitory activities,which may provide a novel chemical template for the development of agents targeting autoimmune and inflammatory diseases.

外文关键词：

Aspergillus amoenus TJ507Nucleoside derivativesIntramolecular transesterificationTumor necrosis factor α(TNF-α)

作者：

Yeting Zhang、Zhengyi Shi、Chunhua Zhao、Lanqin Li、Ming Chen、Yunfang Cao、Fengqing Wang、Bo Tao、Xinye Huang、Jieru Guo、Changxing Qi、Weiguang Sun、Yonghui Zhang

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作者单位：

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China

Department of Pharmacy,Tongji Hospital,Tongji Medical college,Huazhong University of Science and Technology,Wuhan 430033,China

Institute of Organ Transplantation,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Key Laboratory of Organ Transplantation,Min-istry of Education,NHC Key Laboratory of Organ Transplantation,Chinese Academy of Medical Sciences,Wuhan 430030,China

出版年：

2025

DOI：

10.1016/S1875-5364(25)60805-3

中国天然药物

中国药科大学,中国药学会

中国天然药物

影响因子：0.859

ISSN：1672-3651

年,卷(期)：2025.23(1)