Exercise Promotes Liver Health:The Regression of Non-alcoholic Fatty Liver Disease from an Epigenetic Perspective
Non-alcoholic fatty liver disease(NAFLD)is a metabolic disease associated with ge-netics and unhealthy lifestyle.Changes in epigenetic modifications are closely related to the oc-currence and development of NAFLD.Epigenetic modifications can be influenced by environ-mental factors such as diet and exercise.Therefore,based on the environmental-genetic category,this review investigated the role of epigenetic modifications in the pathogenesis of NAFLD and the potential mechanisms by which exercise improves NAFLD through epigenetic modifica-tions pathway.It was found that exercise can directly or indirectly alleviate hepatic steatosis by regulating DNA methylation modification levels in multiple organs/tissues such as liver and skeletal muscle.Exercise can also regulate the expression of genes related to hepatic glucose and lipid metabolism through histone modifications,and improve diet-induced abnormalities in hepatic glucose and lipid metabolism.Additionally,exercise can regulate the expression of non-coding RNA,such as microRNA and long non-coding RNA.It can regulate the mechanisms of lipid synthesis and decomposition,autophagy,insulin signaling,and then improve hepatic lipid deposition related to NAFLD.Importantly,the metabolic benefits of exercise through epigenetic modifications demonstrated evident intergenerational genetic effects.This provided a novel re-search perspective for exercise in prevention and treatment of NAFLD.
NETL
NSTL
万方数据
维普
