Research Progress on the Mechanisms of Wall Shear Stress in Exercise Intervention for Vascular Endothelial Dysfunction
Vascular endothelial dysfunction is the initial link in the development of cardiovascu-lar diseases.Wall shear stress is an important vascular mechanical factor that plays an important role in maintaining vascular endothelial function.Wall shear stress can activate downstream sig-nal transduction,as well as gene and protein expression,thereby directly affecting endothelial cell morphology,metabolism and inflammatory phenotype,and promoting the occurrence and development of vascular endothelial dysfunction.Exercise,as a non-clinical intervention therapy,can stimulate blood flow to different degrees and have a positive effect on vascular endothelial function.Through reviewing the occurrence of vascular endothelial dysfunction,as well as the dose-effect relationship and correlating molecular mechanisms between exercise adaption of vascular endothelial function and wall shear stress,the research discovers the unique characteristics of wall shear stress in improving vascular endothelial dysfunction through different methods,times and intensities of exercise.
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