Ameliorating Effects and Mechanisms of Exerkines on Mitochondrial Dysfunction of Neurons
Mitochondrial dysfunction in neurons is an important factor leading to neuronal dam-age and inducing central nervous system(CNS)diseases.The mechanism by which exerkines ameliorate mitochondrial dysfunction in neurons remains to be elucidated.This study systemati-cally reviewed the roles of neural nutrition factors,nerve cell factors,adipocyte factors,energy metabolism products,and other factors such as Irisin and Neurturin,in mitochondrial quality con-trol and energy metabolism of neurons,oxidative stress,and apoptosis signals,revealing the sig-naling pathways and mechanisms by which exercise factors improve mitochondrial dysfunction in neurons.It has been found that exercise can stimulate the secretion of skeletal muscle,fat,liver and brain exerkines to regulate systemic metabolism through dialogue,as well as improve mito-chondrial dysfunction in neurons through multiple peripheral central interaction pathways.This positive effect is probable that the result of the interaction and crosstalk of the"exerkines net-work",and revealing the precise mechanisms of specific exercise programs and body adapta-tions mediated by exerkines may be a direction for future research.
exerkinesneuronsmitochondrial dysfunctioncentral nervous system diseases
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