Research on the Effects of Hyperbaric Oxygen Therapy Combined with Astaxanthin Intervention on the Elimination of Acute Exercise-Induced Fatigue in Rugby Players
Objective:To explore the effects of hyperbaric oxygen intervention combined with strong antioxidant astaxanthin on the elimination of acute exercise-induced fatigue through com-paring the differences of natural recovery,hyperbaric oxygen intervention and hyperbaric oxygen combined with astaxanthin intervention on the elimination of acute exercise-induced fatigue in rugby players. Methods:Thirty professional rugby players (fifteen males and fifteen females) were recruited and paired and randomly assigned into control group,hyperbaric oxygen group,or hyperbaric oxygen astaxanthin groups (ten in each groups,respectively). Acute fatigue for the three groups was induced by using an exhaustive exercise with incremental load. The control group naturally recovered for 60 min,the hyperbaric oxygen group received 60 min hyperbaric oxygen intervention (ATA=1.3),and the hyperbaric oxygen astaxanthin group took astaxanthin (16 mg) immediately after exercise and then received 60 min hyperbaric oxygen intervention (ATA=1.3). Blood samples were collected at three time points immediately before the exercise (P0),immediately after the exercise (P1),and immediately after the intervention (P2). Changes of inflammation and metabolism-related indicators (WBC,CRP,Bla,BU,UA,Glu,etc.),oxidative stress injury-related indicators (CK,LDH,MDA,SOD,GSH-Px,etc.),and hormone indicators were analyzed. Oxygen saturation indicators including arterial oxygen saturation (SaO2) and muscle oxygen saturation (SmO2) were collected simultaneously. Descriptive statistics and one-way and repeated measure ANOVAs were used to detect significant differences of the subjects' basic information and exhaustion index,and the results of other indicators among the three groups. Results:For the hyperbaric oxygen astaxanthin group,the blood lactate concentration (Bla) was restored to the initial level at P2 (P>0.05),whereas the other two groups remained high;the SmO2 were restored to initial level at P2 for both the hyperbaric oxygen group and the hyperbaric oxygen astaxanthin group (P>0.05),while the control group remained significantly lower (P<0.01). In comparing with the control group and hyperbaric oxygen group,the recov-ery trend of WBC and CRP was more obvious in the hyperbaric oxygen astaxanthin group,and the decrement of CK was more significant (P<0.01,P=0.078). For the hyperbaric oxygen astax-anthin group,the MDA level was reduced from 4.08 mmol/mL at P1 to (3.34±0.24) mmol/mL at P2 (P<0.01),which was significantly lower than the control group (3.84±0.17) mmol/mL (P<0.01),and the hyperbaric oxygen group (3.68±0.29) mmol/mL (P<0.01). Conclusions:Hyperbaric oxygen intervention can effectively promote the recovery of muscle oxygen satura-tion levels after intensive exercise. The intervention of hyperbaric oxygen combined with astax-anthin can accelerate lactic acid metabolism and inhibit inflammation,and can effectively allevi-ate oxidative stress injury caused by the intensive exercise and hyperbaric oxygen intervention,and has a better effect on the elimination of acute exercise-induced fatigue.
exercise-induced fatiguehyperbaric oxygenastaxanthinincremental load exercise to exhaustionoxidative damage
万方数据
维普
