胃癌新辅助治疗后病理完全缓解的意义及治疗策略
Significance and treatment strategies of pathologic complete response after neoadjuvant therapy for gastric cancer
陈杰 1刘凤林1
作者信息
- 1. 复旦大学附属肿瘤医院胃外二科 复旦大学上海医学院肿瘤学系,上海 200032
- 折叠
摘要
新辅助治疗作为局部进展期胃癌综合治疗中的重要一环,已被各大指南所推荐.部分局部进展期胃癌患者在经过新辅助治疗后,可以达到病理完全缓解,从而获得相对较好的预后.但局部病理学上的完全缓解是否都能转化成生存获益仍存争议;获得病理完全缓解的患者是否等同于治愈、后续是否需要辅助治疗,这些均尚未明确.因此,如何预测新辅助治疗后能够达到病理完全缓解的患者以及甄别出真正治愈的患者是未来探索的方向.
Abstract
Neoadjuvant therapy,as an important part of comprehensive treatment for locally advanced gastric cancer,has been recommended by various guidelines.Partial locally advanced gastric cancer patients can achieve pathologic complete response(pCR)after neoadjuvant therapy,thus achieving relatively good prognosis.However,there is still controversy over whether complete remission in local pathology can translate into survival benefits,whether pCR is equivalent to cure,and whether subsequent adjuvant therapy is needed.Therefore,how to predict patients who can achieve pathologic complete response after neoadjuvant therapy and identify truly cured patients is the direction of future exploration.
关键词
胃肿瘤/新辅助治疗/病理完全缓解/预后Key words
Stomach neoplasms/Neoadjuvant therapy/Pathological complete response/Prognosis引用本文复制引用
基金项目
国家自然科学基金(82373381)
国家自然科学基金(82172803)
出版年
2024
NETL
NSTL
万方数据