首页|Effect of applied electric fields on supralinear dendritic integration of interneuron

Effect of applied electric fields on supralinear dendritic integration of interneuron

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
  • 维普
Evidences show that electric fields(EFs)induced by the magnetic stimulation could modulates brain activities by regulating the excitability of GABAergic interneuron.However,it is still unclear how and why the EF-induced polarization affects the interneuron response as the interneuron receives NMDA synaptic inputs.Considering the key role of NMDA receptor-mediated supralinear dendritic integration in neuronal computations,we suppose that the applied EFs could func-tionally modulate interneurons'response via regulating dendritic integration.At first,we build a simplified multi-dendritic circuit model with inhomogeneous extracellular potentials,which characterizes the relationship among EF-induced spa-tial polarizations,dendritic integration,and somatic output.By performing model-based singular perturbation analysis,it is found that the equilibrium point of fast subsystem can be used to asymptotically depict the subthreshold input-output(sI/O)relationship of dendritic integration.It predicted that EF-induced strong depolarizations on the distal dendrites re-duce the dendritic saturation output by reducing driving force of synaptic input,and it shifts the steep change of sI/O curve left by reducing stimulation threshold of triggering NMDA spike.Also,the EF modulation prefers the global dendritic integration with asymmetric scatter distribution of NMDA synapses.Furthermore,we identify the respective contribution of EF-regulated dendritic integration and EF-induced somatic polarization to an action potential generation and find that they have an antagonistic effect on AP generation due to the varied NMDA spike threshold under EF stimulation.

GABAergic interneuronelectrical fieldsupralinear dendritic integrationaction potential genera-tion

樊亚琴、魏熙乐、卢梅丽、伊国胜

展开 >

Tianjin Key Laboratory of Process Measurement and Control,School of Electrical and Information Engineering,Tianjin University,Tianjin 300072,China

School of Information Technology Engineering,Tianjin University of Technology and Education,Tianjin 300222,China

National Natural Science Foundation of ChinaTianjin Municipal Education Commission Scientific Research Project,China

621713122020KJ114

2024

10.1088/1674-1056/ad09cc

中国物理B(英文版)
中国物理学会和中国科学院物理研究所

中国物理B(英文版)

CSTPCDEI
影响因子：0.995
ISSN：1674-1056
年,卷(期)：2024.33(2)
  • 30