首页|Cholesterol-induced deformation of the gramicidin A channel inhibiting potassium ion binding and transport

Cholesterol-induced deformation of the gramicidin A channel inhibiting potassium ion binding and transport

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Gramicidin A(gA)is a kind of antibiotic peptide produced by bacillus brevis and it can dimerize across lipid bilayers to form a monovalent cation channel.In this work,we investigate the impact of cholesterol in the lipid bilayer on the binding of potassium ions with the gA channel and the transport of the ions across the channel.The results indicate that cholesterol can significantly influence the conformational stability of the gA channel and cause the channel deformation which inhibits the potassium ion binding with the channel and transport across the channel.The work provides some molecular insights into understanding of influence of lipids on the activity of gA channel in both model membranes and plasma membranes of intact cells.

gramicidin Alipid bilayermolecular dynamicsinteraction

肖盼、曹宇、朱瑾、梁清

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Center for Statistical and Theoretical Condensed Matter Physics & Department of Physics,Zhejiang Normal University,Jinhua 321004,China

Zhejiang Institute of Photoelectronics & Zhejiang Institute for Advanced Light Source,Zhejiang Normal University,Jinhua 321004,China

国家自然科学基金浙江省自然科学基金

11674287LY19A040009

2024

10.1088/1674-1056/ad334e

中国物理B(英文版)
中国物理学会和中国科学院物理研究所

中国物理B(英文版)

CSTPCDEI
影响因子：0.995
ISSN：1674-1056
年,卷(期)：2024.33(5)
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