首页|Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing

Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing

扫码查看
原文链接
  • NETL
  • NSTL
  • 万方数据
The Hodgkin-Huxley model assumes independent ion channel activation,although mutual interactions are common in biological systems.This raises the problem why neurons would favor independent over cooperative channel activation.In this study,we evaluate how cooperative activation of sodium channels affects the neuron's information processing and energy consumption.Simulations of the stochastic Hodgkin-Huxley model with cooperative activation of sodium chan-nels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron's energy consumption.As a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information processing.This discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.

energy efficiencyion channel noiseaction potential generationneuronal dynamics

严浩然、颜家琦、俞连春、邵玉峰

展开 >

School of Physical Science and Technology,Lanzhou Center for Theoretical Physics,Lanzhou University,Lanzhou 730000,China

Key Laboratory of Theoretical Physics of Gansu Province,and Key Laboratory of Quantum Theory and Applications of MoE,Lanzhou University,Lanzhou 730000,China

Department of Neuroscience,Anatomy,Histology,and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China

中央高校基本科研业务费专项上海市科技计划重大项目Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(LCNBI)ZJLab国家自然科学基金

lzujbky-2021-622018SHZDZX0112247101

2024

10.1088/1674-1056/ad21f5

中国物理B(英文版)
中国物理学会和中国科学院物理研究所

中国物理B(英文版)

CSTPCDEI
影响因子：0.995
ISSN：1674-1056
年,卷(期)：2024.33(5)
  • 21