Tuning the diffusion constant to optimize the readout of positional information of spatial concentration patterns

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外文摘要：Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organ-isms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffu-sion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional informa-tion.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.

外文关键词：

pattern formationpositional informationmutual informationdiffusion

作者：

江嘉杰、罗春雄、刘峰

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作者单位：

The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics,School of Physics,Peking University,Beijing 100871,China

Center for Quantitative Biology,Peking University,Beijing 100871,China

Wenzhou Institute University of Chinese Academy of Sciences,Wenzhou 325001,China

Key Laboratory of Hebei Province for Molecular Biophysics,Institute of Biophysics,School of Health Science & Biomedical Engineering,Hebei University of Technology,Tianjin 300130,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China

项目编号：

3227129311875076

出版年：

2024

DOI：

10.1088/1674-1056/ad4cda

中国物理B(英文版)

中国物理学会和中国科学院物理研究所

中国物理B(英文版)

CSTPCDEI

影响因子：0.995

ISSN：1674-1056

年,卷(期)：2024.33(8)