A Correlational Study of Violent Aggression and P300 Component in Patients With Schizophrenia
Objective To investigate the correlation between aggressive behavior and event-related potential P300 in patients with schizophrenia.Methods From December 2020 to December 2022,all patients with schizophrenia in department of psychiatry,Fujian Provincial Fuzhou Neuropsychiatric Prevention and Treatment Hospital divided into the violent aggression group with 30 cases and the control group with 31 cases according to the previous personal history and the score of the modified overt aggression scales(MOAS).The general data,the amplitude and latency of P300 components of two groups were compared.Moreover,correlations were calculated between the amplitude and latency of P300 components and MOAS scores of all patients.Results There were no significant differences between the general data of the violent aggression group and the control group(P>0.05),but the amplitude and latency of P300 components were statistically significant(P<0.05).The P300 amplitude decreased significantly(2.818±0.643)μV and the P300 latency prolonged(335.530±20.664)ms significantly in the violent aggression group.The Pearson's correlation analysis demonstrated the patients'latency of P300 was positively correlated with their MOAS score(r=0.580,P<0.05),while their P300 amplitude was negatively correlated with their MOAS score(r=-0.421,P<0.05).Conclusion Schizophrenic patients with violent aggression had more severe cognitive impairment.This study speculated that the amplitude and latency of the P300 component can act as a electrophysiological index to predict and assess schizophrenic patients'violent behaviors.
万方数据
维普
