Detection and Clinical Characteristics of Autoantibody Spectrum in Elderly Patients With Autoimmune Liver Disease
Objective To analyze the value and clinical characteristics of the detection of autoimmune liver disease(AILD)by autoantibody spectrum in the elderly.Methods A total of 90 patients with AILD were selected in Quangang General Hospital,the First Affiliated Hospital of Fujian Medical University from July 2020 to June 2003.According to the condition,they were divided into group A and group B and group C,30 cases each.Group A was autoimmune hepatitis,group B was primary biliary liver disease,group C was primary sclerosing cholangiopathy.All three groups were tested for autoantibody profiles.The results of anti-mitochondrial antibody(AMA),antinuclear antibody(ANA),and soluble liver antigen/liver pancreas(SLA/LP),anti-liver-kidney microsomal(LKM)antibody type Ⅰ,anti-smooth muscle antibody(SMA)titer detection and incidence of comorbidities were compared.Results The positive rate of AMA in group B(90.00%)was higher than that in group A(0)and group C(0),the differences were statistically significant(P<0.05);the positive rate of ANA in group A(93.33%)was higher than that in group B(66.67%)and group C(63.33%),and the differences were statistically significant(P<0.05);there were no significant differences in the positive rate of ANA between group B and group C,and the positive rate of AMA between group A and group C(P>0.05).The positive rate of SLA/LP in group A(40.00%)was higher than that in group B(0)and group C(0),and the differences were statistically significant(P<0.05);the positive rate of anti-LKM antibody type Ⅰ in group A(26.67%)was higher than that in group B(0)and group C(0),the differences were statistically significant(P<0.05);the positive rate of SMA titer(≥1:320)in group A(40.00%)was higher than that in group B(0)and group C(0),and the differences were statistically significant(P<0.05).Incidence of liver cirrhosis group B(60.00%)>group A(20.00%)>group C(0),the differences were statistically significant(P<0.05);the incidence of gallstones with chronic gallbladder in group A(3.33%)was lower than that in group C(46.67%)and group B(23.33%),the differences were statistically significant(P<0.05);there were no significant differences in the incidence of hypertension,peptic ulcer,anemia,chronic hepatitis B,Sjogren's syndrome,systemic lupus erythematosus and rheumatoid arthritis among the three groups(P>0.05).Conclusion Body antibody profiling is of great significance for the diagnosis of AILD in the elderly.There are some differences in the positive rate of antigen antibody detection and complications of different types of AILD.
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