Distribution and Drug Sensitivity of Pathogens in Urinary Tract Infection Patients in a 3A Hospital
Objective To investigate the distribution,drug sensitivity and drug resistance of pathogens in patients with urinary tract infection(UTI)in Zigong Third People's Hospital,so as to help clinicians to select antibiotics reasonably,control nosocomial infection and reduce bacterial drug resistance.Methods A total of 3 802 urine samples were collected from patients with urinary tract infection in Zigong Third People's Hospital from January 2019 to December 2020,and the bacteria identification and drug sensitivity test were carried out by MicroScanWalk/Away-40(SIEMENS,USA)automatic microbial identification and drug sensitivity system.Results Among the 539 isolates,411 were Gram-negative bacteria,accounting for 76.25%.Gram-positive bacteria 128 strains,accounting for 23.75%.The top five strains were Escherichia coli 294 strains(54.55%),Enterococcus faecalis 46 strains(8.53%),Klebsiella pneumoniae 38(7.05%),Enterococcus faecium 23 strains(4.27%)and Proteus mirabilis 15 strains(2.78%).Among the first five Gram-negative bacteria,the resistance rates of Escherichia coli to trimethoprim/sulfamethoxazole,ciprofloxacin,cefazolin and levofloxacin were more than 50.00%,to cefotaxime,ceftriaxone,aztreonam and cefepime were more than 40%,to gentamicin was 35.71%,and the others were less than 30%.Klebsiella pneumoniae had the highest resistance rate to SMZ-TMP(52.63%),followed by cefazolin(42.11%),cefotaxime(36.84%),ciprofloxacin(31.58%)and ceftriaxone(31.58%).Proteus mirabilis were excluded from the natural resistance of antimicrobial agents,the highest resistance rate of SMZ-TMP was 60.00%,followed by ciprofloxacin 53.33%,tobramycin 46.67%,cefazolin,gentamicin and aztreonam were 33.33%,the rest were less than 30.00%.Among the first five Gram-positive bacteria,the resistance of Enterococcus faecalis to tetracycline was 86.96%,erythromycin 76.09%,rifampicin 54.35%,ciprofloxacin 32.61%,levofloxacin and moxifloxacin 30.43%,and the others were all within 30%.The resistant rates of erythromycin,ciprofloxacin and levofloxacin were all 100%,penicillin G was 95.65%,moxifloxacin was 91.30%,rifampicin and amoxicillin/clavulanic acid were 82.61%and tetracycline was 65.22%.The resistance rate to vancomycin was the lowest(4.35%),followed by linezolid(5.26%)and nitrofurantoin(8.70%).Conclusion In the process of diagnosis and treatment,clinicians should strengthen the cooperation with the laboratory,pay attention to the etiology examination of urinary tract infection,combine the laboratory etiology report and drug sensitivity test results in the selection of antimicrobial therapy,use antimicrobial drugs rationally,and curb bacterial resistance.
urinary tract infectionpathogenic bacteriadistribution of pathogenic bacteriadrug sensitivitydrug resistanceantimicrobial agents
万方数据
维普
